Market Overview

Global Protein Expression Market size was valued at around 3.35 billion in 2023 and is expected to reach a value of USD 8.11 billion by 2032, at a CAGR of 10.33% over the forecast period (2024–2032).

The global protein expression market is expanding exponentially, driven by the advancement in biotechnology and the increasing demand for high-quality proteins in various industries like pharmaceuticals, biotechnology, and agriculture. Protein expression is the method by which proteins are synthesized, folded, and post-translationally modified in living organisms with the help of primarily recombinant DNA technology. Higher prevalence of chronic diseases and genetic disorders is one of the key drivers for the protein-based therapeutics market. Enzymes, monoclonal antibodies, and other protein therapeutics are becoming the focal point of biopharmaceutical companies, to which cost-effective high-expression systems for protein expression are necessary. Recombinant proteins are discovered to be used heavily in the development of vaccines, gene therapy, and enzyme replacement therapy. The rise in biologics and biosimilars, coupled with the rising trend towards targeted treatments, has also favoured the market for protein expression as these treatments are likely to necessitate advanced protein production techniques.

A further major driver for growth is increasing application of protein expression in academic and research settings. Stable and scalable protein expression systems are needed to facilitate advancement of proteomics research, drug discovery, and structural biology investigations. As high-throughput screening technology and automation continue to rapidly advance, scientists are now able to express and study proteins at a record pace and volume. Besides, advances in synthetic biology, gene editing enzymes such as CRISPR-Cas9, and the establishment of new expression systems have granted new prospects to protein production that enhance the utility of protein expression systems and push their scope to new boundaries.

The advent of personalized medicine has paved the entry for demand in custom proteins as such customized therapeutics require regulated protein expression platforms that can produce patient-specific or disease-specific proteins. This requirement has spurred breakthroughs in protein engineering aimed at optimizing the expression levels, activity, and stability of proteins. Companies are also focusing on designing innovative and improved expression systems, including mammalian cell-based systems, insect cell-based systems, and yeast-based systems, in order to meet growing needs for high-quality and diversified proteins.

Market Drivers

Increasing demand for biologics

• The main fuel behind the rise in the market for protein expression is the increased creation of protein therapies, for example, monoclonal antibodies and antibody-drug conjugates. Biologics are regularly used to treat cancer, autoimmune conditions, as well as inflammatory conditions. Protein expression market has been increasing because of the regulating agencies globally granting approvals to use biologics commercially. During 2023, the US FDA licensed 17 new biologics, 12 of which were monoclonal antibodies. Advanced protein expression technologies have increasingly become necessary in order to facilitate large-scale manufacturing of these pharmaceutical products. In addition, a growing industry for biologics is reflected in the growth in Biologics License Application (BLA) approvals, and this further encourages the utilization of complex protein expression systems. The protein expression market is being fuelled by the creation of novel therapies for a variety of diseases that have unmet therapeutic needs.

Market Opportunities

Growing emphasis on plant-based and cell-free expression systems

• The growing focus on developing and using plant-based and cell-free expression systems as alternatives to traditional mammalian and bacterial protein expression systems presents several potential opportunities for companies in the business of protein expression. While many recombinant medicinal and industrial proteins have already been biomanufacturer with traditional protein expression technologies, these systems also pose several challenges in terms of protein folding and scalability. As they are less expensive and easier to scale, plant-based and cell-free protein expression (CFPE) methods are increasingly gaining acceptance. Plant-based systems can be scaled more conveniently by expanding plant culture, which leads to lower infrastructure costs and a faster production timeline. The systems are environmentally sustainable as they consume less energy, recycle water, and produce less waste. Especially for complex proteins requiring post-translational modifications, cell-free expression methods bring flexibility and yield along with producing proteins without live cells. LenioBio GmbH (Germany) has demonstrated through platforms such as Alice that cell-free expression systems can produce proteins with high accuracy and at vast scales.

Market Restraining Factors

Renewed focus on small molecules in drug development

• The development of small molecule-based medications has engulfed the attention of the pharmaceutical industry, which is decelerating the increase in biologics and impacting the protein expression industry. Because of their reduced cost, simplicity in operation, and wider therapeutic usage, small molecules are favoured. More than half of the 55 new drugs that the US FDA approved during 2023 were small molecules. This reflected the industry's aggressive interest in such pharmacological modalities. Protein expression market would not increase this much if R&D expenditures for biologics are constrained because of this intense preference for research on small-molecule therapeutics.

Segmentation Analysis

The market scope is segmented because of by Expression Systems, by Product, by Application.

• By Expression Systems

Based on the Expression Systems of the market is segmented into Prokaryotic, Mammalian cell, Insect cell, Yeast, Others.

In 2023, the prokaryotic segment held the largest market share, with 42.22%. since it is relatively easier to handle and attain the primary objectives of research. With favourable attributes such as the capacity to produce recombinant proteins on a large scale in a short time at a reduced cost, the segment is likely to hold a similar position during the forecast period. The incorporation of eukaryotic transcription factors, specifically the QF factor, into E. coli was the focus of a July 2021 Nature article highlighting advancements in prokaryotic synthetic biology. This achievement enables tighter regulation of gene expression and the creation of genetic circuits that maintain strong output signals even at low input levels.

During the forecast period, the mammalian cell segment is expected to grow at the highest rate. Mammalian expression systems have been employed by many pharmaceutical companies for producing and developing protein in fully or transiently generated cell lines. This happens when expression constructs combine with the host genome. the goal and strategy decide how systems are employed. ProteoGenix launched their XtenCHOTM Transient Expression System in March 2022. Their new platform, mammalian cell-based, enhances plasmid stability and optimizes metabolism. This method streamlines the production of recombinant proteins, accelerates early-stage drug discovery, and facilitates up to tenfold protein yields while reducing hands-on time.

• By Product

Based on the Product of the market is segmented into Reagents, Competent cells, Expression vectors, Services, Instruments.

Reagents accounted for the highest market share of 45.1% in 2023 and controlled the market. The market consists of established players such as Thermo Fisher Scientific and Agilent Technologies, Inc. To address the unique needs of transfection and optimize cell culture conditions, the companies offer a wide range of transfection reagents. For instance, by analysing and filtering various DNA structures and expression conditions, Nuclera's eProtein Discovery platform supplies reagents that enhance protein accessibilities. With the use of the method, researchers can ascertain optimal conditions to produce proteins at an industrial scale through testing 192 combinations in just one day.

During the forecast period, the services segment is expected to grow rapidly.  To aid their therapeutic antibody discovery and customised assay development, pharmaceutical and biotech companies are outsourcing protein production and expression more and more to antibody production firms, which is driving the growth.  To maximize protein yield, ProMab Biotechnologies, for instance, offers a Stable Cell Line Development service. For recombinant protein expression applications, their experienced scientific staff generates stable cell lines with high levels of expression with optimised, proprietary technology.

• Regional Snapshots

By region, Insights into the markets in North America, Europe, Asia-Pacific, Latin America and MEA are provided by the study. North America is presently the leading player in the world market for protein expression because of the established pharmaceutical and biotechnology industry, huge research and development (R&D) investments, and strong market player presence. It has a sound healthcare infrastructure, high protein therapeutics demand, and rising government support for biotechnology research. The United States, in specific, is a leader in the creation of high-end protein expression systems and the commercialization of biosimilars and biologics. Moreover, the increasing incidence of chronic diseases and genetic disorders has driven the demand for protein-based therapies, which further strengthens the market's dominance in North America.

The Asia-Pacific region will be the highest growth region for protein expression market. The region is witnessing the accelerated growth of biotechnology and pharmaceutical industries with mounting investments in healthcare infrastructure, enhancing research capacities, and greater emphasis on personalized medicine. China, Japan, and India are turning into the world's significant players in the biotech market, with rising investments in protein production technologies and the growing encouragement from governments to the biotechnology programs. The increasing incidence of diseases, combined with the demand for affordable protein therapeutics, is also driving market growth in this region. Also, the ready availability of trained labour at reasonable prices has encouraged Asia-Pacific as a destination for outsourcing protein manufacturing, which has fuelled its strong growth in the protein expression market.

List of Companies Profiled

• Agilent Technologies, Inc.
• Bio-Rad Laboratories
• Thermo Fisher Scientific, Inc.
• Merck Millipore
• New England BioLabs, Inc.
• Promega Corporation
• QIAGEN
• Takara Bio, Inc.
• Oxford Expression Technologies
• Lucigen Corporation

Key Industry Developments

In April 2024, Thomson and Expression Systems collaborated to show how effectively Thomson's Optimum Growth flasks and Expression Systems' ESF AdvanCD cell culture media complement each other to maximize protein yield. The consistency of this partnership's steady growth of cells and high expression levels across a variety of flask sizes and volumes of cultures was shown to represent a reliable and scalable manufacturing platform.

In January 2023, Famous for its advancement in protein sequencing, Quantum-Si Incorporated recently made a collaboration announcement with Aviva Systems Biology, a top provider of protein reagents and antibodies. The aim of this collaboration is to collaborate to develop protein enrichment kits that will allow for an in-depth study of proteins and their variations, or proteoforms, with enhanced protein sequencing techniques.

Report Coverage

The report will cover the qualitative and quantitative data on the Global Protein Expression Market. The qualitative data includes latest trends, market players analysis, market drivers, market opportunity, and many others. Also, the report quantitative data includes market size for every region, country, and segments according to your requirements. We can also provide customize report in every industry vertical.

Report Scope and Segmentations

Regional Snapshots:

The global protein expression market is expected to experienced growth in all regions, including North America, Europe, Asia Pacific, Latin America and Middle east and Africa. Here is some information on the market in each of these regions.

North America: The North American protein expression market is driven by the presence of several biotechnology and pharmaceutical companies, and a strong focus on R&D. The US is the largest market in this region due to the presence of major market players and increasing investments in biotechnology research.

Europe: The European protein expression market is driven by increasing investments in R&D activities, growing demand for biologics, and a well-established healthcare infrastructure. The UK, Germany, and France are the major markets in this region due to their large base of biotechnology and pharmaceutical companies.

Asia Pacific: The Asia Pacific protein expression market is driven by increasing investments in biotechnology research and development, rising demand for biologics, and growing healthcare expenditure. China, Japan, and India are the major markets in this region due to their large population base, rising healthcare infrastructure, and growing biotechnology industry.

Latin America: The Latin American protein expression market is driven by increasing government initiatives to promote biotechnology research and development, growing healthcare infrastructure, and rising demand for biologics. Brazil, Mexico, and Argentina are the major markets in this region due to their large population base and growing biotechnology industry.

Middle East and Africa: The Middle East and Africa protein expression market is driven by increasing investments in biotechnology research and development, growing healthcare infrastructure, and rising demand for biologics. The major markets in this region include Saudi Arabia, South Africa, and United Arab Emirates.

Protein Expression Market Report is also available for below Regions and Country Please Ask for that

North America

• U.S
• Canada

Europe

• Switzerland
• Belgium
• Germany
• France
• U.K
• Italy
• Spain
• Sweden
• Netherland
• Turkey
• Rest of Europe

Asia-Pacific

• India
• Australia
• Philippines
• Singapore
• South Korea
• Japan
• China
• Malaysia
• Thailand
• Indonesia
• Rest Of APAC

Latin America

• Mexico
• Argentina
• Peru
• Colombia
• Brazil
• Rest of South America

Middle East and Africa

• Saudi Arabia
• UAE
• Egypt
• South Africa
• Rest Of MEA

Points Covered in the Report:

• The points that are discussed within the report are the major market players that are involved in the market such as market players, raw material suppliers, equipment suppliers, end users, traders, distributors and etc.
• The complete profile of the companies is mentioned. And the capacity, production, price, revenue, cost, gross, gross margin, sales volume, sales revenue, consumption, growth rate, import, export, supply, future strategies, and the technological developments that they are making are also included within the report. This report analysed 5 years data history and forecast.
• The growth factors of the market are discussed in detail wherein the different end users of the market are explained in detail.
• Data and information by market player, by region, by type, by application and etc., and custom research can be added according to specific requirements.
• The report contains the SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of the industrial experts are included.

Key Questions

• How much the global Protein Expression Market valued?
• Which region has the largest share in 2024 for the global Protein Expression Market?
• What are the driving factors for the market?
• Which is the leading segment in the global market?
• What are the major players in the market?

Research Scope of Protein Expression Market:

• Historic year: 2019-2022
• Base year: 2023
• Forecast: 2024 to 2032
• Representation of Market revenue in USD Million

Protein Expression Market Trends: Market key trends which include Increased Competition and Continuous Innovations Trends: